The 2010 International Symposium on Mechanical Science and Technology (ISMST 2010) will take place in Guangzhou, China, September 25-27, 2010. The aim of this annual symposium is to present the latest scientific results in new fields of mechanical engineering. The ISMST 2010 will serve as good platforms for academic and industry professionals to discuss the latest issues and progress in several subjects. The ISMST 2010 will also publish high quality papers which are closely related to these subjects. All papers, both invited and contributed, will be refereed by two or three referees. After a strict refereeing process, all accepted papers will be published in international journal Advanced Science Letters, which is SCI-Expanded journal and is indexed in Science Citation Index-Expanded database and other famous academy database. We expect that the conference and its publications will be a trigger for further related research and technology improvements in these important subjects.